6MKL

X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with GRL-142

Summary for 6MKL

• Entry DOI: 10.2210/pdb6mkl/pdb
• Related: 4HLA 5TYR 5TYS 6MK9
• Descriptor: Protease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate (3 entities in total)
• Functional Keywords: protease-inhibitor complex, darunavir-resistance, p51, grl-142, non-peptidic, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22458.25

Authors

Yedidi, R.S.,Hayashi, H.,Das, D.,Mitsuya, H. (deposition date: 2018-09-25, release date: 2019-10-02, Last modification date: 2023-10-11)

• Primary citation: Yedidi, R.S.,Hayashi, H.,Das, D.,Mitsuya, H.; Structure-function analysis of darunavir-resistant-P51 HIV-1 protease in complex with GRL-142.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)