6MHR

Structure of the human 4-1BB / Urelumab Fab complex

Summary for 6MHR

• Entry DOI: 10.2210/pdb6mhr/pdb
• Related: 6MGE 6MGP
• Descriptor: Urelumab Fab heavy chain, Urelumab Fab kappa chain, Tumor necrosis factor receptor superfamily member 9, ... (9 entities in total)
• Functional Keywords: signaling, tnfrsf, 4-1bb, cd137, immune system, therapeutic antibody, complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 131534.30

Authors

Kimberlin, C.R.,Chin, S.M.,Roe-Zurz, Z.,Xu, A.,Yang, Y. (deposition date: 2018-09-18, release date: 2018-11-21, Last modification date: 2020-07-29)

• Primary citation: Chin, S.M.,Kimberlin, C.R.,Roe-Zurz, Z.,Zhang, P.,Xu, A.,Liao-Chan, S.,Sen, D.,Nager, A.R.,Oakdale, N.S.,Brown, C.,Wang, F.,Yang, Y.,Lindquist, K.,Yeung, Y.A.,Salek-Ardakani, S.,Chaparro-Riggers, J.; Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.; Nat Commun, 9:4679-4679, 2018; PubMed: 30410017; DOI: 10.1038/s41467-018-07136-7

Experimental method

X-RAY DIFFRACTION (2.8 Å)