6MHD

Glutathione S-Transferase Omega 1 bound to covalent inhibitor 44

Summary for 6MHD

Entry DOI	10.2210/pdb6mhd/pdb
Related	6MHB 6MHC
Descriptor	Glutathione S-transferase omega-1, N-[(3-methyl-1,2-oxazol-5-yl)methyl]-N-(4-phenyl-1,3-thiazol-2-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	transferase, transferase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	56905.64
Authors	Petrunak, E.M.,Stuckey, J.A. (deposition date: 2018-09-17, release date: 2019-02-20, Last modification date: 2023-10-11)
Primary citation	Dai, W.,Samanta, S.,Xue, D.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,Sun, D.,Wu, Y.,Neamati, N. Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors. J. Med. Chem., 62:3068-3087, 2019 Cited by PubMed: 30735370 DOI: 10.1021/acs.jmedchem.8b01960 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation