6MHC
Glutathione S-Transferase Omega 1 bound to covalent inhibitor 37
Summary for 6MHC
Entry DOI | 10.2210/pdb6mhc/pdb |
Related | 6MHB |
Descriptor | Glutathione S-transferase omega-1, methyl N-(4-phenyl-1,3-thiazol-2-yl)-N-propanoylglycinate, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | transferase, transferase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 57111.92 |
Authors | Petrunak, E.M.,Stuckey, J.A. (deposition date: 2018-09-17, release date: 2019-02-20, Last modification date: 2023-10-11) |
Primary citation | Dai, W.,Samanta, S.,Xue, D.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,Sun, D.,Wu, Y.,Neamati, N. Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors. J. Med. Chem., 62:3068-3087, 2019 Cited by PubMed: 30735370DOI: 10.1021/acs.jmedchem.8b01960 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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