6MHB

Glutathione S-Transferase Omega 1 bound to covalent inhibitor 18

6MHB の概要

• エントリーDOI: 10.2210/pdb6mhb/pdb
• 分子名称: Glutathione S-transferase omega-1, N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, transferase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 169614.06

構造登録者

Petrunak, E.M.,Stuckey, J.A. (登録日: 2018-09-17, 公開日: 2019-02-20, 最終更新日: 2023-10-11)

• 主引用文献: Dai, W.,Samanta, S.,Xue, D.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,Sun, D.,Wu, Y.,Neamati, N.; Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.; J. Med. Chem., 62:3068-3087, 2019; PubMed: 30735370; DOI: 10.1021/acs.jmedchem.8b01960

実験手法

X-RAY DIFFRACTION (2.75 Å)