6MFP

Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1

Summary for 6MFP

• Entry DOI: 10.2210/pdb6mfp/pdb
• Related PRD ID: PRD_001094
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, M48U1 CD4 MIMETIC PEPTIDE, DH677.3 Fab heavy chain, ... (7 entities in total)
• Functional Keywords: anti-hiv-1 env antibody dh677.3, cd4i antibody, adcc, hiv-1 env, immune system, rv305 vaccine trial, hiv-1 gp120, clade a/e 93th057, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 8
• Total formula weight: 186096.56

Authors

Tolbert, W.D.,Young, B.,Pazgier, M. (deposition date: 2018-09-11, release date: 2019-09-18, Last modification date: 2023-11-15)

• Primary citation: Easterhoff, D.,Pollara, J.,Luo, K.,Tolbert, W.D.,Young, B.,Mielke, D.,Jha, S.,O'Connell, R.J.,Vasan, S.,Kim, J.,Michael, N.L.,Excler, J.L.,Robb, M.L.,Rerks-Ngarm, S.,Kaewkungwal, J.,Pitisuttithum, P.,Nitayaphan, S.,Sinangil, F.,Tartaglia, J.,Phogat, S.,Kepler, T.B.,Alam, S.M.,Wiehe, K.,Saunders, K.O.,Montefiori, D.C.,Tomaras, G.D.,Moody, M.A.,Pazgier, M.,Haynes, B.F.,Ferrari, G.; Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.; J.Virol., 94:-, 2020; PubMed: 31776278; DOI: 10.1128/JVI.01120-19

Experimental method

X-RAY DIFFRACTION (3 Å)