6ME6

XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin

6ME6 の概要

• エントリーDOI: 10.2210/pdb6me6/pdb
• 分子名称: Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: gpcr, melatonin receptor type 1b (mt2), membrane protein, 2-phenylmelatonin, xfel, lcp, bril, rubredoxin, circadian rhythm, jetlag, type 2 diabetes
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104067.85

構造登録者

Johansson, L.C.,Stauch, B.,McCorvy, J.,Han, G.W.,Patel, N.,Batyuk, A.,Gati, C.,Li, C.,Grandner, J.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V. (登録日: 2018-09-05, 公開日: 2019-04-24, 最終更新日: 2023-10-11)

• 主引用文献: Johansson, L.C.,Stauch, B.,McCorvy, J.D.,Han, G.W.,Patel, N.,Huang, X.P.,Batyuk, A.,Gati, C.,Slocum, S.T.,Li, C.,Grandner, J.M.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Yous, S.,Stevens, R.C.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V.; XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.; Nature, 569:289-292, 2019; PubMed: 31019305; DOI: 10.1038/s41586-019-1144-0

実験手法

X-RAY DIFFRACTION (2.8 Å)