6ME3
XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin
Summary for 6ME3
Entry DOI | 10.2210/pdb6me3/pdb |
Descriptor | chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, OLEIC ACID, ... (5 entities in total) |
Functional Keywords | gpcr, melatonin receptor type 1a (mt1), 2-phenylmelatonin, membrane protein, xfel, lcp, pgs, circadian rhythm, jetlag |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 57294.31 |
Authors | Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Gati, C.,Batyuk, A.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Olsen, R.H.J.,Tribo, A.R.,Weierstall, U.,Roth, B.L.,Katritch, V.,Liu, W.,Cherezov, V. (deposition date: 2018-09-05, release date: 2019-04-24, Last modification date: 2023-10-11) |
Primary citation | Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Huang, X.P.,Gati, C.,Batyuk, A.,Slocum, S.T.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Shiriaeva, A.,Olsen, R.H.J.,Tribo, A.R.,Yous, S.,Stevens, R.C.,Weierstall, U.,Katritch, V.,Roth, B.L.,Liu, W.,Cherezov, V. Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569:284-288, 2019 Cited by PubMed: 31019306DOI: 10.1038/s41586-019-1141-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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