6MDV

Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan

Summary for 6MDV

• Entry DOI: 10.2210/pdb6mdv/pdb
• Descriptor: Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: glycoside hydrolase, endo-beta-n-acetylglucosaminidase s2, endoglycosidase s2, endos2, hydrolase
• Biological source: Streptococcus pyogenes
• Total number of polymer chains: 2
• Total formula weight: 184394.95

Authors

Klontz, E.H.,Trastoy, B.,Orwenyo, J.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J. (deposition date: 2018-09-05, release date: 2019-02-06, Last modification date: 2023-10-11)

• Primary citation: Klontz, E.H.,Trastoy, B.,Deredge, D.,Fields, J.K.,Li, C.,Orwenyo, J.,Marina, A.,Beadenkopf, R.,Gunther, S.,Flores, J.,Wintrode, P.L.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J.; Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.; ACS Cent Sci, 5:524-538, 2019; PubMed: 30937380; DOI: 10.1021/acscentsci.8b00917

Experimental method

X-RAY DIFFRACTION (2.5 Å)