6MB4

Binary (sisomicin) structure of AAC-IIIb

6MB4 の概要

• エントリーDOI: 10.2210/pdb6mb4/pdb
• 分子名称: Aac(3)-IIIb protein, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total)
• 機能のキーワード: acetyltransferase, promiscuity, gnat, antibiotic resistance, antibiotic, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 116522.72

構造登録者

Cuneo, M.J.,Kumar, P. (登録日: 2018-08-29, 公開日: 2018-11-07, 最終更新日: 2023-10-11)

• 主引用文献: Kumar, P.,Selvaraj, B.,Serpersu, E.H.,Cuneo, M.J.; Encoding of Promiscuity in an Aminoglycoside Acetyltransferase.; J. Med. Chem., 61:10218-10227, 2018; PubMed: 30347146; DOI: 10.1021/acs.jmedchem.8b01393

実験手法

X-RAY DIFFRACTION (2.302 Å)