6MAY

Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax

6MAY の概要

• エントリーDOI: 10.2210/pdb6may/pdb
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRADEC-13-YNOIC ACID - COA THIOESTER, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: ssgcid, glycylpeptide n-tetradecanoyltransferase, n-myristoyltransferase, nmt, plasmodium vivax, salvador i, structural genomics, seattle structural genomics center for infectious disease, transferase
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 145437.35

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2018-08-29, 公開日: 2019-06-05, 最終更新日: 2024-03-13)

• 主引用文献: Schlott, A.C.,Mayclin, S.,Reers, A.R.,Coburn-Flynn, O.,Bell, A.S.,Green, J.,Knuepfer, E.,Charter, D.,Bonnert, R.,Campo, B.,Burrows, J.,Lyons-Abbott, S.,Staker, B.L.,Chung, C.W.,Myler, P.J.,Fidock, D.A.,Tate, E.W.,Holder, A.A.; Structure-Guided Identification of Resistance Breaking Antimalarial N‐Myristoyltransferase Inhibitors.; Cell Chem Biol, 26:991-, 2019; PubMed: 31080074; DOI: 10.1016/j.chembiol.2019.03.015

実験手法

X-RAY DIFFRACTION (2.05 Å)