6MAU
Crystal structure of human BRD4(1) in complex with CN210 (compound 19)
Summary for 6MAU
Entry DOI | 10.2210/pdb6mau/pdb |
Descriptor | Bromodomain-containing protein 4, 1-(4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(3S)-3-phenylmorpholin-4-yl]quinazolin-2-yl}-1H-pyrazol-1-yl)-2-methylpropan-2-ol, GLYCEROL, ... (4 entities in total) |
Functional Keywords | brd4(1), protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15946.30 |
Authors | Nadupalli, A.,Fontano, E.,Connors, C.R.,Chan, S.G.,Olland, A.M.,Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2018-08-28, release date: 2019-04-03, Last modification date: 2024-03-13) |
Primary citation | Yang, S.M.,Yoshioka, M.,Strovel, J.W.,Urban, D.J.,Hu, X.,Hall, M.D.,Jadhav, A.,Maloney, D.J. Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases. Bioorg. Med. Chem. Lett., 29:1220-1226, 2019 Cited by PubMed: 30905542DOI: 10.1016/j.bmcl.2019.03.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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