6MAU

Crystal structure of human BRD4(1) in complex with CN210 (compound 19)

6MAU の概要

• エントリーDOI: 10.2210/pdb6mau/pdb
• 分子名称: Bromodomain-containing protein 4, 1-(4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[(3S)-3-phenylmorpholin-4-yl]quinazolin-2-yl}-1H-pyrazol-1-yl)-2-methylpropan-2-ol, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: brd4(1), protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15946.30

構造登録者

Nadupalli, A.,Fontano, E.,Connors, C.R.,Chan, S.G.,Olland, A.M.,Lakshminarasimhan, D.,White, A.,Suto, R.K. (登録日: 2018-08-28, 公開日: 2019-04-03, 最終更新日: 2024-03-13)

• 主引用文献: Yang, S.M.,Yoshioka, M.,Strovel, J.W.,Urban, D.J.,Hu, X.,Hall, M.D.,Jadhav, A.,Maloney, D.J.; Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.; Bioorg. Med. Chem. Lett., 29:1220-1226, 2019; PubMed: 30905542; DOI: 10.1016/j.bmcl.2019.03.014

実験手法

X-RAY DIFFRACTION (2.11 Å)