6MAP

F9 Pilus Adhesin FmlH Lectin Domain from E. coli UTI89 in Complex with Galactoside 5-nitro-2'-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-[1,1'-biphenyl]-3-carboxylic acid

6MAP の概要

• エントリーDOI: 10.2210/pdb6map/pdb
• 分子名称: Fimbrial adhesin FmlD, SULFATE ION, 2'-(beta-D-galactopyranosyloxy)-5-nitro[1,1'-biphenyl]-3-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: pilus, adhesin, galactose, lectin, sugar binding protein, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
• 由来する生物種: Escherichia coli UTI89
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19139.11

構造登録者

Klein, R.D.,Hultgren, S.J. (登録日: 2018-08-28, 公開日: 2019-09-04, 最終更新日: 2023-12-13)

• 主引用文献: Maddirala, A.R.,Klein, R.,Pinkner, J.S.,Kalas, V.,Hultgren, S.J.,Janetka, J.W.; Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.; J.Med.Chem., 62:467-479, 2019; PubMed: 30540910; DOI: 10.1021/acs.jmedchem.8b01561

実験手法

X-RAY DIFFRACTION (1.08 Å)