6MA3

Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 2a

6MA3 の概要

• エントリーDOI: 10.2210/pdb6ma3/pdb
• 分子名称: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host Cell Factor 1 peptide, 4-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl)methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}butanoic acid, ... (4 entities in total)
• 機能のキーワード: ogt, o-glcnac, glycosyltransferase, enzyme-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83196.76

構造登録者

Martin, S.E.S.,Lazarus, M.B.,Walker, S. (登録日: 2018-08-25, 公開日: 2018-10-17, 最終更新日: 2023-10-11)

• 主引用文献: Martin, S.E.S.,Tan, Z.W.,Itkonen, H.M.,Duveau, D.Y.,Paulo, J.A.,Janetzko, J.,Boutz, P.L.,Tork, L.,Moss, F.A.,Thomas, C.J.,Gygi, S.P.,Lazarus, M.B.,Walker, S.; Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.; J. Am. Chem. Soc., 140:13542-13545, 2018; PubMed: 30285435; DOI: 10.1021/jacs.8b07328

実験手法

X-RAY DIFFRACTION (2 Å)