6M7H

Structure of calmodulin with KN93

6M7H の概要

• エントリーDOI: 10.2210/pdb6m7h/pdb
• 分子名称: Calmodulin-1, N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: ca2+ binding ef-hand inhibitor complex, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18630.76

構造登録者

Damo, S.M.,Pattanayek, R.,Johnson, C.N. (登録日: 2018-08-20, 公開日: 2019-08-28, 最終更新日: 2019-11-27)

• 主引用文献: Johnson, C.N.,Pattanayek, R.,Potet, F.,Rebbeck, R.T.,Blackwell, D.J.,Nikolaienko, R.,Sequeira, V.,Le Meur, R.,Radwanski, P.B.,Davis, J.P.,Zima, A.V.,Cornea, R.L.,Damo, S.M.,Gyorke, S.,George Jr., A.L.,Knollmann, B.C.; The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.; Cell Calcium, 82:102063-102063, 2019; PubMed: 31401388; DOI: 10.1016/j.ceca.2019.102063

実験手法

X-RAY DIFFRACTION (1.6 Å)