6M6X

Oridonin in complex with CRM1#-Ran-RanBP1

Summary for 6M6X

• Entry DOI: 10.2210/pdb6m6x/pdb
• Related: 5YSU 6M60
• Descriptor: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (9 entities in total)
• Functional Keywords: active ran, complex, transport protein, inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 157780.96

Authors

Sun, Q.,Lei, Y. (deposition date: 2020-03-16, release date: 2021-03-17, Last modification date: 2023-11-29)

• Primary citation: Lei, Y.,Li, Y.,Tan, Y.,Qian, Z.,Zhou, Q.,Jia, D.,Sun, Q.; Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.; J.Nat.Prod., 84:1478-1488, 2021; PubMed: 33890470; DOI: 10.1021/acs.jnatprod.0c01231

Experimental method

X-RAY DIFFRACTION (2.88 Å)