6M6K

NMR solution structure of a DNA minidumbbell containing an abasic bulge between two CCTG repeats

6M6K の概要

• エントリーDOI: 10.2210/pdb6m6k/pdb
• NMR情報: BMRB: 36326
• 分子名称: DNA (5'-D(*CP*TP*TP*GP*(3DR)P*CP*TP*TP*G)-3'), SODIUM ION (2 entities in total)
• 機能のキーワード: minidumbbell, abasic site, bulge, cc mispair, dna
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2742.58

構造登録者

Wan, L.,Lam, S.L.,Guo, P. (登録日: 2020-03-15, 公開日: 2020-07-29, 最終更新日: 2024-05-01)

主引用文献

Wan, L.,Lam, S.L.,Lee, H.K.,Guo, P.
Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell.
Chem.Commun.(Camb.), 56:10127-10130, 2020

PubMed Abstract: Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.

PubMed: 32870195
DOI: 10.1039/d0cc03774e

実験手法

SOLUTION NMR