6M5O
Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Summary for 6M5O
Entry DOI | 10.2210/pdb6m5o/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCINE, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 113620.89 |
Authors | Ota, T.,Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. (deposition date: 2020-03-11, release date: 2021-01-20, Last modification date: 2023-11-29) |
Primary citation | Ota, T.,Senoo, A.,Shirakawa, M.,Nonaka, H.,Saito, Y.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. Iscience, 24:102036-102036, 2021 Cited by PubMed: 33521601DOI: 10.1016/j.isci.2021.102036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.30000663987 Å) |
Structure validation
Download full validation report