6M5O

Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

6M5O の概要

• エントリーDOI: 10.2210/pdb6m5o/pdb
• 分子名称: Serine hydroxymethyltransferase, mitochondrial, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCINE, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113620.89

構造登録者

Ota, T.,Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. (登録日: 2020-03-11, 公開日: 2021-01-20, 最終更新日: 2023-11-29)

• 主引用文献: Ota, T.,Senoo, A.,Shirakawa, M.,Nonaka, H.,Saito, Y.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S.; Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.; Iscience, 24:102036-102036, 2021; PubMed: 33521601; DOI: 10.1016/j.isci.2021.102036

実験手法

X-RAY DIFFRACTION (2.30000663987 Å)