6M49
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
Summary for 6M49
Entry DOI | 10.2210/pdb6m49/pdb |
EMDB information | 30074 |
Descriptor | Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein, 25-HYDROXYCHOLESTEROL (3 entities in total) |
Functional Keywords | scap, insig, cholesterol, sterol sensing, 25-hydroxycholesterol, srebp, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 88447.72 |
Authors | |
Primary citation | Yan, R.,Cao, P.,Song, W.,Qian, H.,Du, X.,Coates, H.W.,Zhao, X.,Li, Y.,Gao, S.,Gong, X.,Liu, X.,Sui, J.,Lei, J.,Yang, H.,Brown, A.J.,Zhou, Q.,Yan, C.,Yan, N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science, 371:-, 2021 Cited by PubMed: 33446483DOI: 10.1126/science.abb2224 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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