6M3I

Crystal structure of HPF1/PARP1 complex

Summary for 6M3I

• Entry DOI: 10.2210/pdb6m3i/pdb
• Descriptor: Histone PARylation factor 1, Poly [ADP-ribose] polymerase 1, BENZAMIDE, ... (4 entities in total)
• Functional Keywords: complex, adp-ribosylation, dna damage response, nuclear protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 67673.36

Authors

Sun, F.H.,Yun, C.H. (deposition date: 2020-03-03, release date: 2021-03-03, Last modification date: 2023-11-29)

• Primary citation: Sun, F.H.,Zhao, P.,Zhang, N.,Kong, L.L.,Wong, C.C.L.,Yun, C.H.; HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.; Nat Commun, 12:1028-1028, 2021; PubMed: 33589610; DOI: 10.1038/s41467-021-21302-4

Experimental method

X-RAY DIFFRACTION (1.98 Å)