6M3C

hAPC-h1573 Fab complex

6M3C の概要

• エントリーDOI: 10.2210/pdb6m3c/pdb
• 分子名称: Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, h1573 Fab H chain, ... (4 entities in total)
• 機能のキーワード: human apc, h1573 fab, complex, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 279683.55

構造登録者

Wang, X.,Wang, D.,Zhao, X.,Egner, U. (登録日: 2020-03-03, 公開日: 2020-07-08, 最終更新日: 2023-11-29)

• 主引用文献: Zhao, X.Y.,Wilmen, A.,Wang, D.,Wang, X.,Bauzon, M.,Kim, J.Y.,Linden, L.,Li, L.,Egner, U.,Marquardt, T.,Moosmayer, D.,Tebbe, J.,Gluck, J.M.,Ellinger, P.,McLean, K.,Yuan, S.,Yegneswaran, S.,Jiang, X.,Evans, V.,Gu, J.M.,Schneider, D.,Zhu, Y.,Xu, Y.,Mallari, C.,Hesslein, A.,Wang, Y.,Schmidt, N.,Gutberlet, K.,Ruehl-Fehlert, C.,Freyberger, A.,Hermiston, T.,Patel, C.,Sim, D.,Mosnier, L.O.,Laux, V.; Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.; Nat Commun, 11:2992-2992, 2020; PubMed: 32532974; DOI: 10.1038/s41467-020-16720-9

実験手法

X-RAY DIFFRACTION (3.7 Å)