6M12
Crystal Structure of Rnase L in complex with SU11652
Summary for 6M12
Entry DOI | 10.2210/pdb6m12/pdb |
Descriptor | Ribonuclease L, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, rnase l, su11652, hydrolase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 2 |
Total formula weight | 165911.68 |
Authors | |
Primary citation | Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H. Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J., 477:3387-3399, 2020 Cited by PubMed: 32830849DOI: 10.1042/BCJ20200260 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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