6M0T

Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin derivative (CL-2)

Summary for 6M0T

• Entry DOI: 10.2210/pdb6m0t/pdb
• Related: 4PG3
• Descriptor: Lysine--tRNA ligase, LYSINE, (3R)-3-[(R)-[(2R,6S)-6-methyloxan-2-yl]-oxidanyl-methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, ... (4 entities in total)
• Functional Keywords: cladosporin analog, stereochemistry, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 4
• Total formula weight: 236649.82

Authors

Babbar, P.,Sharma, A.,Manickam, Y. (deposition date: 2020-02-22, release date: 2021-04-21, Last modification date: 2023-11-29)

• Primary citation: Babbar, P.,Das, P.,Manickam, Y.,Mankad, Y.,Yadav, S.,Parvez, S.,Sharma, A.,Reddy, D.S.; Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites.; Acs Infect Dis., 7:1777-1794, 2021; PubMed: 33843204; DOI: 10.1021/acsinfecdis.1c00092

Experimental method

X-RAY DIFFRACTION (2.68 Å)