6LZZ

Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a

Summary for 6LZZ

• Entry DOI: 10.2210/pdb6lzz/pdb
• Descriptor: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 77100.41

Authors

Huang, Y.Y.,Wu, Y.,Luo, H.B. (deposition date: 2020-02-19, release date: 2021-02-24, Last modification date: 2023-11-29)

• Primary citation: Tian, Y.J.,Zhou, Q.,Zhang, P.,Jiang, M.Y.,Zhang, B.,Wu, X.N.,Zhang, C.,Li, Z.,Wu, Y.,Chen, Z.,Luo, H.B.; Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.40003752238 Å)