6LX5
X-ray structure of human PPARalpha ligand binding domain-ciprofibrate co-crystals obtained by delipidation and co-crystallization
Summary for 6LX5
| Entry DOI | 10.2210/pdb6lx5/pdb |
| Descriptor | Peroxisome proliferator-activated receptor alpha, GLYCEROL, 2-{4-[(1S)-2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid, ... (4 entities in total) |
| Functional Keywords | nuclear receptor, protein-ligand complex, ppar, transcription |
| Biological source | Homo sapiens |
| Total number of polymer chains | 2 |
| Total formula weight | 62960.82 |
| Authors | Kamata, S.,Saito, K.,Honda, A.,Ishikawa, R.,Oyama, T.,Ishii, I. (deposition date: 2020-02-10, release date: 2020-11-11, Last modification date: 2023-11-29) |
| Primary citation | Kamata, S.,Oyama, T.,Saito, K.,Honda, A.,Yamamoto, Y.,Suda, K.,Ishikawa, R.,Itoh, T.,Watanabe, Y.,Shibata, T.,Uchida, K.,Suematsu, M.,Ishii, I. PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23:101727-101727, 2020 Cited by PubMed: 33205029DOI: 10.1016/j.isci.2020.101727 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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