6LSN
Crystal structure of tubulin-inhibitor complex
Summary for 6LSN
Entry DOI | 10.2210/pdb6lsn/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, ... (13 entities in total) |
Functional Keywords | inhibitor, cell cycle |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 6 |
Total formula weight | 264889.47 |
Authors | Gang, L.,Wang, Y.X.,Cheng, J.J. (deposition date: 2020-01-17, release date: 2021-01-20, Last modification date: 2023-11-29) |
Primary citation | Gang, L.,Wang, Y.X.,Chen, J.J. Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.445 Å) |
Structure validation
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