6LSN

Crystal structure of tubulin-inhibitor complex

6LSN の概要

• エントリーDOI: 10.2210/pdb6lsn/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, ... (13 entities in total)
• 機能のキーワード: inhibitor, cell cycle
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 264889.47

構造登録者

Gang, L.,Wang, Y.X.,Cheng, J.J. (登録日: 2020-01-17, 公開日: 2021-01-20, 最終更新日: 2023-11-29)

• 主引用文献: Gang, L.,Wang, Y.X.,Chen, J.J.; Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities; To Be Published,

実験手法

X-RAY DIFFRACTION (2.445 Å)