6LS5

Structure of human liver FBPase complexed with covalent allosteric inhibitor

6LS5 の概要

• エントリーDOI: 10.2210/pdb6ls5/pdb
• 分子名称: Fructose-1,6-bisphosphatase 1, 2-(ethyldisulfanyl)-1,3-benzothiazole, ADENOSINE MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: fbpase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 156819.51

構造登録者

Yunyuan, H.,Rongrong, S.,Yixiang, X.,Shuaishuai, N.,Yanliang, R.,Jian, L.,Jian, W. (登録日: 2020-01-17, 公開日: 2020-05-27, 最終更新日: 2023-11-29)

• 主引用文献: Huang, Y.,Xu, Y.,Song, R.,Ni, S.,Liu, J.,Xu, Y.,Ren, Y.,Rao, L.,Wang, Y.,Wei, L.,Feng, L.,Su, C.,Peng, C.,Li, J.,Wan, J.; Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.; J.Med.Chem., 63:6238-6247, 2020; PubMed: 32375478; DOI: 10.1021/acs.jmedchem.0c00699

実験手法

X-RAY DIFFRACTION (2.031 Å)