6LRZ

Crystal structure of Keap1 in complex with dimethyl fumarate (DMF)

6LRZ の概要

• エントリーDOI: 10.2210/pdb6lrz/pdb
• 分子名称: Keap1-DC, dimethyl (~{E})-but-2-enedioate, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: beta-propeller domain, oxidative stress, keap1-nrf2 system, dmf, inhibitor complex, cytosolic protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35337.28

構造登録者

Padmanabhan, B.,Unni, S.,Deshmukh, P. (登録日: 2020-01-16, 公開日: 2020-08-05, 最終更新日: 2023-11-29)

• 主引用文献: Unni, S.,Deshmukh, P.,Krishnappa, G.,Kommu, P.,Padmanabhan, B.; Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.; Febs J., 288:1599-1613, 2021; PubMed: 32672401; DOI: 10.1111/febs.15485

実験手法

X-RAY DIFFRACTION (1.54 Å)