6LRM

Crystal structure of PDE4D catalytic domain in complex with arctigenin

Summary for 6LRM

• Entry DOI: 10.2210/pdb6lrm/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde4d, inhibitor, complex structure, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 82730.73

Authors

Zhang, X.L.,Li, M.J.,Xu, Y.C. (deposition date: 2020-01-16, release date: 2021-04-14, Last modification date: 2023-11-29)

Primary citation

Li, H.,Zhang, X.,Xiang, C.,Feng, C.,Fan, C.,Liu, M.,Lu, H.,Su, H.,Zhou, Y.,Qi, Q.,Xu, Y.,Tang, W.
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation.
J Adv Res, 33:241-251, 2021

PubMed Abstract: Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects. Nevertheless, the potential therapeutic target of arctigenin in modulating inflammation remains undefined.

PubMed: 34603793
DOI: 10.1016/j.jare.2021.02.006

Experimental method

X-RAY DIFFRACTION (1.45 Å)