6LRM

Crystal structure of PDE4D catalytic domain in complex with arctigenin

6LRM の概要

• エントリーDOI: 10.2210/pdb6lrm/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: pde4d, inhibitor, complex structure, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82730.73

構造登録者

Zhang, X.L.,Li, M.J.,Xu, Y.C. (登録日: 2020-01-16, 公開日: 2021-04-14, 最終更新日: 2023-11-29)

主引用文献

Li, H.,Zhang, X.,Xiang, C.,Feng, C.,Fan, C.,Liu, M.,Lu, H.,Su, H.,Zhou, Y.,Qi, Q.,Xu, Y.,Tang, W.
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation.
J Adv Res, 33:241-251, 2021

PubMed Abstract: Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects. Nevertheless, the potential therapeutic target of arctigenin in modulating inflammation remains undefined.

PubMed: 34603793
DOI: 10.1016/j.jare.2021.02.006

実験手法

X-RAY DIFFRACTION (1.45 Å)