6LQG
Human gamma-secretase in complex with small molecule Avagacestat
Summary for 6LQG
Entry DOI | 10.2210/pdb6lqg/pdb |
EMDB information | 0944 |
Descriptor | Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total) |
Functional Keywords | small molecule, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 184334.94 |
Authors | |
Primary citation | Yang, G.,Zhou, R.,Guo, X.,Yan, C.,Lei, J.,Shi, Y. Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184:521-533.e14, 2021 Cited by PubMed: 33373587DOI: 10.1016/j.cell.2020.11.049 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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