6LNY

The co-crystal structure of Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease with aldehyde M15

Summary for 6LNY

Entry DOI	10.2210/pdb6lny/pdb
Descriptor	Replicase polyprotein 1a, (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide (3 entities in total)
Functional Keywords	severe acute respiratory syndrome coronavirus, 3c like protease, hydrolase
Biological source	Human SARS coronavirus (SARS-CoV)
Total number of polymer chains	1
Total formula weight	34290.15
Authors	Wang, H.,Shang, L.Q. (deposition date: 2020-01-02, release date: 2020-05-27, Last modification date: 2023-11-29)
Primary citation	Wang, H.,He, S.,Deng, W.,Zhang, Y.,Li, G.,Sun, J.,Zhao, W.,Guo, Y.,Yin, Z.,Li, D.,Shang, L. Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease. Acs Catalysis, 10:5871-5890, 2020 Cited by PubMed: 32391184 DOI: 10.1021/acscatal.0c00110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.245 Å)

Structure validation