6LNY

The co-crystal structure of Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease with aldehyde M15

6LNY の概要

• エントリーDOI: 10.2210/pdb6lny/pdb
• 分子名称: Replicase polyprotein 1a, (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide (3 entities in total)
• 機能のキーワード: severe acute respiratory syndrome coronavirus, 3c like protease, hydrolase
• 由来する生物種: Human SARS coronavirus (SARS-CoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34290.15

構造登録者

Wang, H.,Shang, L.Q. (登録日: 2020-01-02, 公開日: 2020-05-27, 最終更新日: 2023-11-29)

• 主引用文献: Wang, H.,He, S.,Deng, W.,Zhang, Y.,Li, G.,Sun, J.,Zhao, W.,Guo, Y.,Yin, Z.,Li, D.,Shang, L.; Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease.; Acs Catalysis, 10:5871-5890, 2020; PubMed: 32391184; DOI: 10.1021/acscatal.0c00110

実験手法

X-RAY DIFFRACTION (2.245 Å)