6LNQ

The co-crystal structure of SARS-CoV 3C Like Protease with aldehyde inhibitor M7

6LNQ の概要

• エントリーDOI: 10.2210/pdb6lnq/pdb
• 分子名称: Severe Acute Respiratory Syndrome Coronavirus 3c Like Protease, N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxidanylidene-1-[[(2S)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-1-oxidanylidene-butan-2-yl]-1H-indole-2-carboxamide (3 entities in total)
• 機能のキーワード: coronavirus 3c, protease, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Severe acute respiratory syndrome-related coronavirus (SARSr-CoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34388.25

構造登録者

Wang, H.,Shang, L.Q. (登録日: 2020-01-01, 公開日: 2020-05-27, 最終更新日: 2023-11-22)

• 主引用文献: Wang, H.,He, S.,Deng, W.,Zhang, Y.,Li, G.,Sun, J.,Zhao, W.,Guo, Y.,Yin, Z.,Li, D.,Shang, L.; Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease.; Acs Catalysis, 10:5871-5890, 2020; PubMed: 32391184; DOI: 10.1021/acscatal.0c00110

実験手法

X-RAY DIFFRACTION (2.244 Å)