6LN1

A natural inhibitor of DYRK1A for treatment of diabetes mellitus

6LN1 の概要

• エントリーDOI: 10.2210/pdb6ln1/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one (3 entities in total)
• 機能のキーワード: anti-diabetic activity, desmethylbellidifolin, dyrk1a, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81477.85

構造登録者

Li, H.,Chen, L.X.,Zheng, M.Z.,Zhang, Q.Z.,Zhang, C.L.,Wu, C.R.,Yang, K.Y.,Song, Z.R.,Wang, Q.Q.,Li, C.,Zhou, Y.R.,Chen, J.C. (登録日: 2019-12-28, 公開日: 2021-10-06, 最終更新日: 2023-11-22)

• 主引用文献: Zheng, M.,Zhang, Q.,Zhang, C.,Wu, C.,Yang, K.,Song, Z.,Wang, Q.,Li, C.,Zhou, Y.,Chen, J.,Li, H.,Chen, L.; A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes.; Clin Transl Med, 11:e494-e494, 2021; PubMed: 34323401; DOI: 10.1002/ctm2.494

実験手法

X-RAY DIFFRACTION (2.699 Å)