6LJL

Crystal Structure of exoHep-Y390A/H555A complexed with a tetrasaccharide substrate

6LJL の概要

• エントリーDOI: 10.2210/pdb6ljl/pdb
• 分子名称: Heparinase II/III-like protein, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: heparin, heparan sulfate, heparinase, crystall, lyase
• 由来する生物種: Bacteroides intestinalis DSM 17393
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 101053.33

構造登録者

Zhang, Q.D.,Cao, H.Y.,Wei, L.,Li, F.C.,Zhang, Y.Z. (登録日: 2019-12-17, 公開日: 2020-12-23, 最終更新日: 2023-11-22)

• 主引用文献: Zhang, Q.,Cao, H.Y.,Wei, L.,Lu, D.,Du, M.,Yuan, M.,Shi, D.,Chen, X.,Wang, P.,Chen, X.L.,Chi, L.,Zhang, Y.Z.,Li, F.; Discovery of exolytic heparinases and their catalytic mechanism and potential application.; Nat Commun, 12:1263-1263, 2021; PubMed: 33627653; DOI: 10.1038/s41467-021-21441-8

実験手法

X-RAY DIFFRACTION (1.73 Å)