6LIL
Crystal structure of human PDK2 complexed with an allosteric inhibitor compound 8c
Summary for 6LIL
Entry DOI | 10.2210/pdb6lil/pdb |
Descriptor | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | mitochondria, kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 94270.88 |
Authors | |
Primary citation | Kang, J.,Pagire, H.S.,Kang, D.,Song, Y.H.,Lee, I.K.,Lee, K.T.,Park, C.J.,Ahn, J.H.,Kim, J. Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds. Biochem.Biophys.Res.Commun., 527:778-784, 2020 Cited by PubMed: 32444142DOI: 10.1016/j.bbrc.2020.04.102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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