6LIL

Crystal structure of human PDK2 complexed with an allosteric inhibitor compound 8c

6LIL の概要

• エントリーDOI: 10.2210/pdb6lil/pdb
• 分子名称: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• 機能のキーワード: mitochondria, kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94270.88

構造登録者

Kang, J.,Kim, J. (登録日: 2019-12-12, 公開日: 2020-09-30, 最終更新日: 2023-11-22)

• 主引用文献: Kang, J.,Pagire, H.S.,Kang, D.,Song, Y.H.,Lee, I.K.,Lee, K.T.,Park, C.J.,Ahn, J.H.,Kim, J.; Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds.; Biochem.Biophys.Res.Commun., 527:778-784, 2020; PubMed: 32444142; DOI: 10.1016/j.bbrc.2020.04.102

実験手法

X-RAY DIFFRACTION (1.93 Å)