6LHJ
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C452 (compound 16) and NADPH
6LHJ の概要
エントリーDOI | 10.2210/pdb6lhj/pdb |
分子名称 | Bifunctional dihydrofolate reductase-thymidylate synthase, 1-[3-(2-chloranyl-4-fluoranyl-phenoxy)propoxy]-6,6-dimethyl-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
機能のキーワード | inhinitor, antifolate, dyhydrofolate reductase, plasmodium falciparum, antibiotic, oxidoreductase |
由来する生物種 | Plasmodium falciparum (malaria parasite P. falciparum) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 146703.13 |
構造登録者 | |
主引用文献 | Kamchonwongpaisan, S.,Charoensetakul, N.,Srisuwannaket, C.,Taweechai, S.,Rattanajak, R.,Vanichtanankul, J.,Vitsupakorn, D.,Arwon, U.,Thongpanchang, C.,Tarnchompoo, B.,Vilaivan, T.,Yuthavong, Y. Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities. Eur.J.Med.Chem., 195:112263-112263, 2020 Cited by PubMed: 32294614DOI: 10.1016/j.ejmech.2020.112263 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
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