6LDB
Structure of Bifidobacterium dentium beta-glucuronidase complexed with uronic isofagomine
Summary for 6LDB
Entry DOI | 10.2210/pdb6ldb/pdb |
Descriptor | LacZ1 Beta-galactosidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid (3 entities in total) |
Functional Keywords | inhibitor, glycosidase, isofagomine, hydrolase |
Biological source | Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1) |
Total number of polymer chains | 4 |
Total formula weight | 298999.22 |
Authors | Lin, H.-Y.,Hsieh, T.-J.,Lin, C.-H. (deposition date: 2019-11-20, release date: 2021-01-27, Last modification date: 2023-11-22) |
Primary citation | Lin, H.Y.,Chen, C.Y.,Lin, T.C.,Yeh, L.F.,Hsieh, W.C.,Gao, S.,Burnouf, P.A.,Chen, B.M.,Hsieh, T.J.,Dashnyam, P.,Kuo, Y.H.,Tu, Z.,Roffler, S.R.,Lin, C.H. Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4:280-280, 2021 Cited by PubMed: 33664385DOI: 10.1038/s42003-021-01815-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.651 Å) |
Structure validation
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