6L97

Complex of DNA polymerase IV and L-DNA duplex

6L97 の概要

• エントリーDOI: 10.2210/pdb6l97/pdb
• 分子名称: DNA polymerase IV, DNA (5'-D(P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DT)P*(0DC)P*(0DC)P*(0DT)P*(0DT)P*(0DC)P*(0DC)P*(0DC)P*(0DC)P*(0DC))-3'), DNA (5'-D(*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DG)P*(0DG)P*(0DA)P*(0DT)P*(0DT)P*(0DC)P*(0DC))-3'), ... (4 entities in total)
• 機能のキーワード: dpo4, l-dna duplex, dna polymerase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92416.37

構造登録者

Chung, H.S.,An, J.,Hwang, D. (登録日: 2019-11-08, 公開日: 2020-07-08, 最終更新日: 2023-11-22)

主引用文献

An, J.,Choi, J.,Hwang, D.,Park, J.,Pemble 4th, C.W.,Duong, T.H.M.,Kim, K.R.,Ahn, H.,Chung, H.S.,Ahn, D.R.
The crystal structure of a natural DNA polymerase complexed with mirror DNA.
Chem.Commun.(Camb.), 56:2186-2189, 2020

PubMed Abstract: The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

PubMed: 31971182
DOI: 10.1039/c9cc09351f

実験手法

X-RAY DIFFRACTION (2.362 Å)