6L76
Crystal structure of the Ni(II)(Chro)2-d(TTGGGCCGAA/TTCGGCCCAA) complex at 2.94 angstrom resolution
Summary for 6L76
Entry DOI | 10.2210/pdb6l76/pdb |
Descriptor | DNA (5'-D(*TP*TP*GP*GP*GP*CP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*GP*CP*CP*CP*AP*A)-3'), 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, ... (7 entities in total) |
Functional Keywords | duplex dna, ggggcc motif, nucleotide flipping-out, hoogsteen base pair, dna |
Biological source | synthetic construct More |
Total number of polymer chains | 4 |
Total formula weight | 17275.98 |
Authors | Hou, M.H.,Jhan, C.R.,Satange, R.B.,Lin, S.M. (deposition date: 2019-10-31, release date: 2021-01-13, Last modification date: 2023-11-22) |
Primary citation | Jhan, C.R.,Satange, R.,Wang, S.C.,Zeng, J.Y.,Horng, Y.C.,Jin, P.,Neidle, S.,Hou, M.H. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res., 49:9526-9538, 2021 Cited by PubMed: 33836081DOI: 10.1093/nar/gkab227 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
Download full validation report