6L6E
Human PDE5 catalytic core in complex with avanafil
6L6E の概要
エントリーDOI | 10.2210/pdb6l6e/pdb |
分子名称 | cGMP-specific 3',5'-cyclic phosphodiesterase, 4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide, ZINC ION, ... (6 entities in total) |
機能のキーワード | phosphodiesterase isoform 5, avanafil, enzyme-drug complex, co-crystallization, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 39660.59 |
構造登録者 | |
主引用文献 | Hsieh, C.M.,Chen, C.Y.,Chern, J.W.,Chan, N.L. Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting alpha-Helix Backbone Oxygen by Halogen Bonding. J.Med.Chem., 63:8485-8494, 2020 Cited by PubMed: 32663396DOI: 10.1021/acs.jmedchem.0c00853 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.92 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)