6L4Q

Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-B

Summary for 6L4Q

• Entry DOI: 10.2210/pdb6l4q/pdb
• Related: 4PG3
• Descriptor: Lysine--tRNA ligase, (3R)-3-[[(3R)-3-methylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, ... (4 entities in total)
• Functional Keywords: cladosporin analog, stereochemistry, amino-acyl trna synthetase, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 2
• Total formula weight: 118290.94

Authors

Babbar, P.,Sharma, A.,Manickam, Y.,Mishra, S.,Harlos, K. (deposition date: 2019-10-19, release date: 2021-05-19, Last modification date: 2023-11-22)

• Primary citation: Babbar, P.,Sato, M.,Manickam, Y.,Mishra, S.,Harlos, K.,Gupta, S.,Parvez, S.,Kikuchi, H.,Sharma, A.; Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B; Chembiochem, 2021; DOI: 10.1002/cbic.202100212

Experimental method

X-RAY DIFFRACTION (3.1 Å)