6L17

Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives

6L17 の概要

• エントリーDOI: 10.2210/pdb6l17/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazin-8-amine (3 entities in total)
• 機能のキーワード: pim-1 kinase, 10-debc, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33651.58

構造登録者

Zhang, W.,Xie, Y.,Cao, R.,Huang, N.,Zhou, Y. (登録日: 2019-09-27, 公開日: 2020-09-02)

• 主引用文献: Li, G.,Zhang, W.,Xie, Y.,Li, Y.,Cao, R.,Zheng, G.,Huang, N.,Zhou, Y.; Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors.; J.Chem.Inf.Model., 60:3287-3294, 2020; PubMed: 32407627; DOI: 10.1021/acs.jcim.0c00245

実験手法

X-RAY DIFFRACTION (1.75 Å)