6L16
Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives
Summary for 6L16
Entry DOI | 10.2210/pdb6l16/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl)ethyl]piperidin-1-yl]ethanamine (3 entities in total) |
Functional Keywords | pim-1 kinase, 10-debc, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33665.61 |
Authors | |
Primary citation | Li, G.,Zhang, W.,Xie, Y.,Li, Y.,Cao, R.,Zheng, G.,Huang, N.,Zhou, Y. Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60:3287-3294, 2020 Cited by PubMed: 32407627DOI: 10.1021/acs.jcim.0c00245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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