6L0B
Crystal structure of dihydroorotase in complex with fluorouracil from Saccharomyces cerevisiae
Summary for 6L0B
Entry DOI | 10.2210/pdb6l0b/pdb |
Related | 6L0A |
Descriptor | Dihydroorotase, ZINC ION, 5-FLUOROURACIL, ... (4 entities in total) |
Functional Keywords | dihydropyrimidinase, dihydroorotase, metalloenzyme, hydrolase |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Total number of polymer chains | 4 |
Total formula weight | 166957.00 |
Authors | Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2019-09-26, release date: 2020-12-02, Last modification date: 2023-11-22) |
Primary citation | Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551:33-37, 2021 Cited by PubMed: 33714757DOI: 10.1016/j.bbrc.2021.03.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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